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br this combination Furthermore repeat
2020-08-12
this combination. Furthermore, repeat studies have shown that a small percentage of these tumors exhibit durable complete regres-sion without the need for further treatment following an initial 2 cycles. This combination also proved safe at target dosing with less than 10% decrease in weight of
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br Mar C induces DNA damage and represses DNA
2020-08-12
3.4. Mar-C induces DNA damage and represses DNA repair As cellular senescence phenotype is often accompanied by the ac-cumulation of DNA damage [20], we tested if DNA damage was in-volved in Mar-C-mediated senescence. As shown in Fig. 4A and B, changes of phosphorylation of H2AX at Ser139 (γ-H2
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Pa and from to Pa when the
2020-08-12
124 ± 8 Pa and from 12 ± 8 to 50 ± 5 Pa, when the concentration of CDEAC hydrogel increased from 1 to 5 wt%, respectively (Fig. 4E). This storage modulus range is comparable to 30–500 Pa characteristic of Matrigel which is widely used for CS growth [49]. The reversibility of gelation/liquefaction co
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br specimens p x The prognostic value
2020-08-12
specimens (p=2.3x10-6). The prognostic value of miR-196a expression has not been tested in our study, however, it has been shown recently that high levels of miR-196 as a plasma biomarker is associated with dismal survival in pancreatic adenocarcinoma patients [29]. ROC analyses for the miR-196a m
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Cellular and Molecular Gastroenterology and Hepatology Vol N
2020-08-12
Cellular and Molecular Gastroenterology and Hepatology Vol. 7, No. 1 treatment, cancer staging, and tumor response and recur-rence were recorded when available (Table 1). The morphology of each patient-derived organoid line (huTGO) was unique (Figure 1A and B). Specifically, we observed that w
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Solasodine br BD cytometric bead array CBA for cytokine anal
2020-08-07
2.10. BD™ cytometric bead array (CBA) for cytokine analysis Effector T Solasodine and ovarian cancer cells were co-cultured as de-scribed previously to determine CAR T cell cytotoxicity at an E/T ratio of 10:1 for 10 h. The supernatant was then collected and the level of cytokines in the supern
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Nutlin-3 br The best method to map axillary positive lymph n
2020-08-07
The best method to map axillary positive Nutlin-3 nodes remains a question. The positioning of a metallic clip using ultrasound guidance into a positive node is simple and can be performed by an experienced surgeon or radiologist. The main difficulty here is the identification and localization of
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br Autophagy regulates stem cell
2020-08-07
3.1.5. Autophagy regulates stem cell maintenance The ability of the stem M3814 (nedisertib) to self-renew and differentiate into several types of cells are bearing great importance for oncogenic pro-cesses as well as development and tissue renewal. Tumor-initiating cells share some characteristi
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br Regarding the non previously described SNP analyzed
2020-08-06
Regarding the non-previously described SNP analyzed, the results obtained showed that patients carrying the rs7459185 CC Ethylmalonyl Coenzyme A located in HSPB1 sequence present a significantly higher risk of acute RIET while LC patient’s harboring the rs11466353 TT/ TG genotypes are associated
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br homogeneous staining of healthy
2020-08-04
homogeneous staining of healthy human pancreas tissue can be readily observed. In addition, highly selective staining of the ductal adeno-carcinoma versus stroma in the human PDAC pancreas tissue is clear. Two different grades of human PDAC pancreas tissue were examined. Fig. 3 shows PanIN tissue,
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br The effect of systemic therapy on
2020-08-04
The effect of systemic therapy on all-cause mortality was analyzed in 2 ways. In the first model (model 1), patients assigned to the post-SRS systemic therapy group received sys-temic therapy at any time before death, including after Stearamide relapse or systemic relapse. In the second model (mo
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br Artemisinin ART and its derivatives have long been used
2020-08-04
Artemisinin (ART) and its derivatives have long been used as anti-malarials due to their efficacy and low toxicity [6–8]. However, recent studies have shown that ART derivatives possess profound anti-tumor activity as well. These studies have shown that ART inhibits the growth of numerous types o
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PFK-158 br Introduction br International agency for research
2020-08-03
1. Introduction International agency for research on cancer in 2012 announced the statistics for all cancers. According to this, breast cancer has been iden-tified as the most frequent malignant disease in women worldwide with an estimated 1.67 million new cases and causes 6.4% of the total dea
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br Gottingen Germany br Nu Nu mice were intraperitoneally in
2020-08-02
Gottingen,€ Germany). Nu/Nu mice were intraperitoneally injected with 1 106 SKOV3-Luc cells to form tumors. After 5 days, BMS-777607 (50 mg/ kg daily) or an equal volume of water (control) was administered orally to these tumor-bearing mice. The tumor growth was moni-tored in terms of luminesce
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A 61603 br Bioluminescent imaging BLI is a visualization tec
2020-08-02
Bioluminescent imaging (BLI) is a visualization tech-nique for tracing A 61603 and tissue, and gene behavior in vivo [15]. BLI is characterized by light scattering and has unique imaging advantages. In addition, tissue and cells have almost no endogenous luminescence and low endogenous signal-to-