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Nutlin-3 br The best method to map axillary positive lymph n
2020-08-07
The best method to map axillary positive Nutlin-3 nodes remains a question. The positioning of a metallic clip using ultrasound guidance into a positive node is simple and can be performed by an experienced surgeon or radiologist. The main difficulty here is the identification and localization of
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br Autophagy regulates stem cell
2020-08-07
3.1.5. Autophagy regulates stem cell maintenance The ability of the stem M3814 (nedisertib) to self-renew and differentiate into several types of cells are bearing great importance for oncogenic pro-cesses as well as development and tissue renewal. Tumor-initiating cells share some characteristi
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br Regarding the non previously described SNP analyzed
2020-08-06
Regarding the non-previously described SNP analyzed, the results obtained showed that patients carrying the rs7459185 CC Ethylmalonyl Coenzyme A located in HSPB1 sequence present a significantly higher risk of acute RIET while LC patient’s harboring the rs11466353 TT/ TG genotypes are associated
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br homogeneous staining of healthy
2020-08-04
homogeneous staining of healthy human pancreas tissue can be readily observed. In addition, highly selective staining of the ductal adeno-carcinoma versus stroma in the human PDAC pancreas tissue is clear. Two different grades of human PDAC pancreas tissue were examined. Fig. 3 shows PanIN tissue,
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br The effect of systemic therapy on
2020-08-04
The effect of systemic therapy on all-cause mortality was analyzed in 2 ways. In the first model (model 1), patients assigned to the post-SRS systemic therapy group received sys-temic therapy at any time before death, including after Stearamide relapse or systemic relapse. In the second model (mo
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br Artemisinin ART and its derivatives have long been used
2020-08-04
Artemisinin (ART) and its derivatives have long been used as anti-malarials due to their efficacy and low toxicity [6–8]. However, recent studies have shown that ART derivatives possess profound anti-tumor activity as well. These studies have shown that ART inhibits the growth of numerous types o
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PFK-158 br Introduction br International agency for research
2020-08-03
1. Introduction International agency for research on cancer in 2012 announced the statistics for all cancers. According to this, breast cancer has been iden-tified as the most frequent malignant disease in women worldwide with an estimated 1.67 million new cases and causes 6.4% of the total dea
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br Gottingen Germany br Nu Nu mice were intraperitoneally in
2020-08-02
Gottingen,€ Germany). Nu/Nu mice were intraperitoneally injected with 1 106 SKOV3-Luc cells to form tumors. After 5 days, BMS-777607 (50 mg/ kg daily) or an equal volume of water (control) was administered orally to these tumor-bearing mice. The tumor growth was moni-tored in terms of luminesce
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A 61603 br Bioluminescent imaging BLI is a visualization tec
2020-08-02
Bioluminescent imaging (BLI) is a visualization tech-nique for tracing A 61603 and tissue, and gene behavior in vivo [15]. BLI is characterized by light scattering and has unique imaging advantages. In addition, tissue and cells have almost no endogenous luminescence and low endogenous signal-to-
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br Introduction br Colorectal cancer CRC is the third
2020-08-02
1. Introduction Colorectal cancer (CRC) is the third most common type of cancer in the world [1]. In 2012, approximately 1.36 million new cases were diagnosed with CRC, out of which 694,000 deaths were reported [2]. Although CRC is more common in developed countries, mortality rate is higher in
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br To confirm the level of miR in each
2020-07-30
To confirm the level of miR-143 in each organ, including tumor, we performed RT-PCR (Figure 5B). As a result, PIC groups showed the highest blood levels of miR-143 among the groups tested. The levels of miR-143#12 in the xenografted tumors were elevated, which would reflect the levels in the blood
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br the IC values for FU increased by fold for
2020-07-27
the IC50 values for 5-FU increased by 2-fold, for Oxa increased by 12-fold, and for Dox by 5-fold, compared to SW48-5FU cells, respectively (Table 1). Consistently, colon cancer WiDr α-CEHC that carry homozygous R273H presented substantial resistance to these drugs, as compared either to SW48-
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br Table br Adjusted and unadjusted predicted satisfaction d
2020-07-27
Table 4 Adjusted and unadjusted predicted satisfaction domain scores by the HRQoL sample mean and standard deviation change (N = 637). Unadjusted satisfaction scores Adjusted satisfaction scores Unadjusted satisfaction scores Adjusted satisfaction scores At Mean At Mean At Mean
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br E mail address zhengb zjams com
2020-07-06
E-mail address: [email protected] (B. Zheng). 1 Contributed equally molecular mechanisms involved in the development of AKT2 in colon cancer remain unknown. The most prominent metabolic feature of tumors is efficient aerobic glycolysis, known as the Warburg effect. In addition, tumor aerobic
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br INTRODUCTION br B reast cancer
2020-03-24
INTRODUCTION B reast cancer is a significant health concern for women, with one in eight expected to be diagnosed with the disease during their lifetime (1). Development of image-based computer-assisted diagnosis of breast cancer can Funding information: This work was supported by the Nation