-
br Cisplatin is a genotoxic
2020-08-30
Cisplatin is a genotoxic agent that is quite effective at killing HPV+ cervical cancers. Cisplatin works by inducing DNA crosslinking that activate many of the same cellular responses induced by UV exposure (McKay et al., 2001). For comparison with the UV-resistant HeLa cells, cisplatin-resistant H
-
br S Walsh D Benten S J
2020-08-30
S. Walsh, D. Benten, S.J. Forbes, R.G. Wells, J.P. Iredale, Matrix stiffness mod-ulates proliferation, chemotherapeutic response, and dormancy in hepato-cellular carcinoma cells, Hepatology 53 (2011) 1192e1205. Contents lists available at ScienceDirect Preventive Medicine journal homepage
-
br Introduction br Ovarian cancer
2020-08-30
1. Introduction Ovarian cancer is one of the most commonly occurring types of cancer and approximately 22,240 new cases of ovarian cancer will be diagnosed in the United States in 2018 (Reid et al., 2017; Siegel et al., 2018). The current standard treatment is a tumorectomy coupled with platin
-
br tients Although initial studies questioned the benefit of
2020-08-30
tients [20, 21, 25]. Although initial studies questioned the benefit of Table 2 Causes of death in older and younger patients. Older group Younger group p Table 3 Causes of death in older patients. All deceased older patients Chemo group Table 4 Demographic Informati
-
br SOX SRY HMG Box is a
2020-08-30
SOX2 (SRY HMG-Box 2) is a transcription factor that regulates oncogenic signaling pathways in different types CSCs. In human lung CSCs, a positive feedback loop between SOX2 and EGFR sustained high tumorigenic properties, and upregu-lation of SOX2 enhanced self-renewability and resistance of cance
-
br Table Primers for Real
2020-08-28
Table 1. Primers for Real-Time RT-PCR Gene Assay Number Human CAMP Human KRT20 Human TUBB1 Human TUBB3 Human FPR2 Human P2RX7 Mouse GAPDH Unisp6 Inventoried primer list of RT-PCR reactions. www.moleculartherapy.org REFERENCES 25. Rejniak, K.A. (2012). Inve
-
Triple negative breast cancer TNBC accounts for of all diagn
2020-08-28
Triple-negative breast cancer (TNBC) accounts for 10–15% of all diagnosed breast cancers and has an aggressive clinical course due to a lack of therapeutic cellular targets [1]. Accumulating clinical evidence demonstrates that TNBC is biologically more aggressive and has a higher Ki-67 proliferation
-
br Fig The structure of
2020-08-18
Fig. 1. The structure of curcumin (A) and bioconjugate AA-CUR (B). (C), Schematic illustration of the micelle formed by conjugate AA-CUR; (D), Network structure scheme of the micelle from bioconjugate AA-CUR crosslinked by Ca2+ ions. group [37,38], thus further confirming the effective conjugati
-
b iframe width height src https
2020-08-18
r> However, to the best of our knowledge, information on the epigenetic effects of BPS is lack at present. While it is too early to speculate whether the epigenetic effects of BPS is similar with BPA, the similarity in their structure and common endocrine-disruption effect warrants investigation on
-
br Conflicts of interest br Authors declare no conflicts of
2020-08-18
Conflicts of interest Authors declare no conflicts of interest. Acknowledgements This work was supported principally by the Department of Biotechnology (Bio-CARe scheme, BT/BioCARe/07/10003/2013-2014) to author Swati Biswas. Appendix A. Supplementary data References Bhadra, D.
-
br Chen M Ouyang H
2020-08-18
95. Chen M, Ouyang H, Zhou S, Li J, Ye Y. [Effect of PLGA nanoparticles conjugated with anti-OX40/anti-AFP mAbs on cytotoxicity of CTL 36531-78-9 against hepatocellular carcinoma]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. Apr 2014;30(4):337-341.
-
Phase I and II study of Auranofin in Chronic Lymphocytic
2020-08-18
[36] Phase I and II study of Auranofin in Chronic Lymphocytic Leukemia (CLL)’. https://clinicaltrials.gov/ct2/show/NCT01419691. [37] PKCi & mTOR Inhibition With AuranofinþSirolimus for Squamous Cell Lung Cancer’. https://clinicaltrials.gov/ct2/show/NCT01737502. [38] Auranofin in Treating Patients
-
br Functional limitations secondary to comorbid conditions
2020-08-18
Functional limitations secondary to comorbid conditions were com-mon among study participants. For some, difficulty with activities of daily living (bathing, dressing) prohibited participation in any physical activity, including walking. Gait and balance issues limited mobility and ambulation f
-
br RNA seq data and qPCR analyses confirmed regulation
2020-08-18
RNA-seq data and qPCR analyses confirmed regulation of BACH1’s previously known—and new Transfac-identified—target genes. For example, Nqo1 expression was lower, and Pkp3 and Mmp1a expression was higher, in mTN than mTC DAPT (Figure 2C). Pkp3 and Mmp1a have been linked to cell invasion (Furuka
-
Autophagy supports stromal cells and promotes tumor growth b
2020-08-18
3.2.5. Autophagy supports stromal cells and promotes tumor growth In most cases, tumor cells hijack stromal cell functions and switch on autophagy to maintain homeostasis and support tumor growth (Zhou et al., 2013). During tumorigenesis, cancer cells induce excessive ROS production, which activa